PureGenomics^{™ B-Complex is designed to address the nutrient requirements of common genetic variations in the methylation pathway with a unique blend of B vitamins in highly researched and activated forms. Folate is offered in this formula as Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the universally metabolized and biologically active form of folate, providing support for individuals with genetic variations in the MTHFR gene. Vitamin B_{12 is offered as a combination of hydroxocobalamin and adenosylcobalamin. Hydroxocobalamin is a precursor form of vitamin B12 converted in the body to both methylcobalamin and adenosylcobalamin. Adenosylcobalamin is an activated form stored in the mitochondria of cellular tissues. It is a key cofactor in carbohydrate metabolism for the enzyme methylmalonyl-CoA mutase, which is used to produce succinyl-CoA. Optimal levels of vitamin B12 also support normal immune function. Benfotiamine is a lipid-soluble, enhanced-retention thiamine derivative. This formula also includes the methyl donor choline, which helps to support liver function.}}